The inner surface crack (ISC) defect easily occurs in seamless modified 9Cr-1Mo steel tubes rolled by the mandrel mill with high production efficiency. The reason for the formation of the ISC lies in both the properties of deformed material and rolling conditions. With the aid of commercial FE code MSC.SuperForm, the rolling process of modified 9Cr-1Mo seamless steel tube produced by the Mandrel Mill of Bao Steel in China was simulated, focusing on mechanical analysis of deformed metal. It was found from the simulation that the metal on the inner surface of the tube, in the position of 0 or 90 of the roll pass, experiences strong tensile stresses, especially the circumferential stress, which is closely related .to the strain behavior governed by the two-high pass caliber of the mandrel mill. Therefore an optimal design of the roll pass can be realized to decrease the tensile stress so as to relax the tendency to the ISC, which has been confirmed by the tests in Steel Tube & Pipe Company of Bao Steel.