The cross-linked UHMWPE mixed with Vitamin E (VE) was prepared by hot press and then irradiated with gamma radial of 100 kGy does. The scratch hardness, micro-hardness and cross-linking density of cross-linked UHMWPE was measured. The tribilogical behavior also was examined. The experimental results indicated that the scratch hardness and micro-hardness of irradiation virgin and NC/UHMWPE are higher than that of virgin UHMWPE. Mixing VE decreased the cross-linking density of irradiated UHMWPE. Friction coefficients of virgin and cross-linked UHMWPE were seldom affected by irradiation and mixing VE. It was ranged from 0.35 to 0.37. Wear rate of virgin and cross-linked UHMWPE were strongly influenced by irradiation and mixing VE. Wear rate had an inverse proportional to the scratch hardness. The cross-linking and mixing VE in UHMWPE change the severity of adhesive wear of UHMWPE. For virgin UHMWPE, irradiated virgin UHMWPE and 0.1wt%VE/UHMWPE, the severity of adhesive wear was gradually decreased. Besides adhesion, poluging was the wear mechanism of irradiated 0.3wt%VE/UHMWPE.