Kinetics Modelling of Vitamin B12 Release in an Agar/κ-Carrageenan Hydrogel Blend

Abstract:

A phycocolloidal hydrogel patch is studied as a potential material for the transdermal delivery device for vitamin B12. The vitamin release kinetics from an agar/κ-carrageenan hydrogel blend as a function of mass ratio and vitamin loading. Concentration measurements were done using a colorimetric method, and the experimental data were fitted into the Korsmeyer-Peppas model, Peppas-Sahlin model, and Berens-Hopfenberg model. From the curve fitting, parameters such as first-order polymer relaxation constant and diffusivity constant were obtained. The results showed that for the Korsmeyer-Peppas model and the Peppas-Sahlin model, the release mechanism followed Fickian diffusion predominantly. On the other hand, the Berens-Hopfenberg model fit shows that the release mechanism predominantly follows non-Fickian diffusion and may need to be modified.

• Periodical: Engineering Chemistry (Volume 3)
• Pages: 31-36
• DOI: https://doi.org/10.4028/p-9cv3vh
• Online since: June 2023
• Authors: Michael Sean P. Deang, Jayke Matthew Fajardo, Dave Taña, Terence Tumolva*
• Keywords: Agar, Carrageenan, Drug Release, Hydrogel, Vitamin

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