Biological Behaviour of Bonelike® Graft Implanted in the Tibia of Humans
This paper reports the ability of Bonelike® to regenerate bone defected areas when implanted in the tibia of 3 patients (average age of 59 years) during a high tibial osteotomy (HTO) to treat medial compartment osteoarthritis of the knee. Bonelike® is a synthetic bone graft designed to mimic the inorganic composition of bone using a patent process that consists of liquid sintering hydroxyapatite in the presence of CaO-P2O5 based glass. The preliminary clinical evaluation performed showed that an intimate contact between new formed bone and Bonelike® was established (67±10 %), with no fibrous interface. Therefore, Bonelike® is a single-handedly viable osteoconductive synthetic grafting material as it has been demonstrated from the profiles of radiological, histological and scanning electron microscopy analyses for the six months implantation period.
Panjian Li, Kai Zhang and Clifford W. Colwell, Jr.
M. Gutierres et al., "Biological Behaviour of Bonelike® Graft Implanted in the Tibia of Humans", Key Engineering Materials, Vols. 284-286, pp. 1041-1044, 2005