Self-setting paste model in bioactive glass systems was investigated. Particulate glasses based on the systems CaO-SiO2-P2O5 and Na2O-CaO-SiO2 were combined with sodium phosphate solution to constitute paste models. Setting behavior of these pastes, i.e., workability and setting within 30 min were obtained by controlled composition-mass conditions. Specifically, it was found that the setting behavior could be controlled by glass compositions as well as mixing ratios of solids and solutions. These suggest new concept of bioactive cement for various biomedical applications.