To improve the cutting efficiency, one of key approaches is to control with constant force in the full depth working condition. And the controller design is vital to realize the real-time feasibility and robustness of the system. A neuron optimization based PID approach is proposed in this paper and adopted in the NC cutting process. This approach optimizes the parameters of PID controller real-timely with the neural network control principle. It not only overcomes the mismatch of the open-loop system model which occurred in constant PID control, but also solves the contradiction between the calculation speed and precision in the neural network which caused by the node choosing of the hidden layer. At last, the simulation has been carried out on a NC milling machine to prove the validity and effectiveness of the proposed approach.