A Novel Approach to Prepare Nano-Hydroxyapatite / Silk Fibroin Composite to Increase Nucleation Sites

Abstract:

A composite of needle-like nano-Hydroxyapatite / silk fibroin (n-HA/SF) with strong interfacial bonding was successfully prepared from calcium chloride (CaCl2) and diammonium phosphate ((NH4)2HPO4) as starting materials of HA in the presence of SF powders dissolved in a ternary solvent system of CaCl2-C2H5OH-H2O (1:2:8 in molar ration) at 80 °C for 30 min prior to preparation of n-HA/SF composite. The n-HA crystals in the composite were poorly crystallized and uniformly distributed in the composite with a crystal size of 4~6 nm in diameter and 20~40 nm in length, which was smaller than that of pure nano-HA. Molecular interaction and strong chemical bonds were formed between n-HA and SF in the composite, which were revealed by Fourier transform infrared spectrometric analysis (FTIR). The synthetic n-HA/SF composite had a good homogeneity and preferential orientation along c-axis and would have a great potential for bone tissue engineering.

• Periodical: Key Engineering Materials (Volumes 330-332)
• Pages: 341-344
• DOI: https://doi.org/10.4028/www.scientific.net/KEM.330-332.341
• Online since: February 2007
• Authors: Jing Wang, Mu Qin Li, Xiang Cai Meng, Guang Wu Wen
• Keywords: Composite Material, Interfacial Bonding, Nano-HA, Silk Fibroin

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