Mn-Zn ferrites with chemical formula (Mn-Zn) Fe2O4 have widespread applications in the electrical and electronics industries. These ferrites are synthesized generally by conventional method. This method, which contains calcination of raw materials, is affected by several parameters such as composition and purity of the raw materials and temperature, time and atmosphere of the process. Optimization of these parameters is very important because these parameters affect the magnetic and electrical properties of the material. In this work, the ratio of the different Iranian routs of the raw materials for production of high Ms ferrite powder has been optimized and the effects of calcination conditions have been investigated using XRD, DTA/TGA techniques. The magnetic properties have also been measured.