Modeling of bionic-bone tissue scaffold is the kernel of the structure design and bionic manufacturing of bionic bone scaffold. According to the growth requirements of new bone tissue cell on the porosity and pore size of bionic bone tissue model, an approach for modeling of bionic-bone tissue scaffold based on the surface model of bone tissue is presented by filling the profile model of bone tissue with the delamination of hollow unit cell. The hollow cubic unit cell is designed with controllable porosity and pore size. The algorithm for filling the profile of bone tissue with delamination of porous unit cell is provided for generating the model of bionic bone with pore structure. The scaffold model is stored in Common Layer Interface (CLI) file for the Rapid Prototyping Manufacturing (RPM) of scaffold.