In this paper, the vulnerability of the multi-storey reinforced concrete is classified and analyzed according to three control factors: construction age, story and uses. And the different categories vulnerability matrices of multi-story reinforced concrete are obtained from the monomer sample buildings which are already evaluated. The proportion of construction area of different categories can be attained from buildings census statistics. Then the vulnerability matrix of concrete building group in study region can be established by sum-product of construction area ratio of each vulnerability class in study region and each class vulnerability matrix. Finally, the vulnerability matrix of reinforced concrete structure of Xi'an Yanliang District was obtained using this approach. After comparing with the traditional earthquake damage prediction method, it is shown that this method is feasible, simple idea and high reliable and can be used for rapid assessment of post earthquake.