Paper Titles

Theoretical and Experimental Studies on Stresses in Vacuum Glazing due to Temperature Difference
p.311

A Study of the Test Method of Coating Adherence of Refractories Used in Cement Kilns
p.316

The Characteristics of Graphene Prepared by Different Methods
p.321

The Durability and Damage Testing of High Performance Concrete
p.325

Structural-Function Integration Optimization of Vacuum Insulation Panel in Construction Area
p.329

Method for Determination of Operating Temperature of Building Photovoltaic Module
p.334

Investigation of Carbon Fiber Wetting Process by Wilhelmy Method and Force Analysis Method
p.338

Application of Clustering Analysis and Discriminant Analysis on Quality Grade Evaluation of Jadeite-Jades’ Green Color
p.343

Instrumental Measurement and Analysis of Pharmaceutical Tablet Texture — A Review
p.348

HomeKey Engineering MaterialsKey Engineering Materials Vol. 591Instrumental Measurement and Analysis of...

Instrumental Measurement and Analysis of Pharmaceutical Tablet Texture — A Review

Article Preview

Abstract:

Textural property is one of the most important attributes of pharmaceutical tablet. From the perspective of destructive and non-destructive methods, this article reviews various approaches of tablet texture measurement and analysis. It is indicated that researchers usually utilize mechanical testers and optical and acoustic instruments to determine texture properties of hardness,tensile strength, friability and porosity of tablet, mainly aiming to characterize the damage and abrasive resistance.

You might also be interested in these eBooks

Testing and Evaluation of Inorganic Materials IV

Info:

Periodical:

Key Engineering Materials (Volume 591)

Pages:

348-353

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.591.348

Citation:

Cite this paper

Online since:

November 2013

Authors:

Ya Qi Cheng, Lan Chen, Mduduzi E.K. Ngcobo

Keywords:

Instrumental Measurement, Mechanical Property, Tablet, Texture

Export:

RIS, BibTeX

Price:

Permissions CCC:

Request Permissions

Permissions PLS:

Request Permissions

Сopyright:

© 2014 Trans Tech Publications Ltd. All Rights Reserved

Share:

Citation:

[1] J.C.O. Villanova, E. Ayres, R.L. Oréfice, Design of prolonged release tablets using new solid acrylic excipients for direct compression, Europ. J. Pharm. Biopharm. 79 (2011) 664–673.

DOI: 10.1016/j.ejpb.2011.07.011

[2] A.B. Joshi, S. Patel, A.M. Kaushal, A.K. Bansal, Compaction studies of alternate solid forms of celecoxib, Advanced Powder Technology. 21 (2010) 452–460.

DOI: 10.1016/j.apt.2010.01.006

[3] F. Podczeck, Methods for the practical determination of the mechanical strength of tablets — From empiricism to science, International Journal of Pharmaceutics. 436 (2012) 214–232.

DOI: 10.1016/j.ijpharm.2012.06.059

[4] L. Chen, U.L. Opara, Texture measurement approaches in fresh and processed foods — A review, Food Research International. 51 (2013) 823–835.

DOI: 10.1016/j.foodres.2013.01.046

[5] F. Fichtner, A, Rasmuson, G. Alderborn, Particle size distribution and evolution in tablet structure during and after compaction, International Journal of Pharmaceutics. 292 (2005) 211–225.

DOI: 10.1016/j.ijpharm.2004.12.003

[6] I. Stoltenberg, J. Breitkreutz, Orally disintegrating mini-tablets (ODMTs) – A novel solid oral dosage form for paediatric use, Europ. J. Pharmaceutics and Biopharmaceutics. 78 (2011) 462–469.

DOI: 10.1016/j.ejpb.2011.02.005

[7] A.S. Narang, V.M. Rao, H. Guo, J. Lu, D.S. Desai, Effect of force feeder on tablet strength during compression, International Journal of Pharmaceutics. 401 (2010) 7–15.

DOI: 10.1016/j.ijpharm.2010.08.027

[8] A. Gryczke, S. Schminke, M. Maniruzzaman, J. Beck, D. Douroumis, Development and evaluation of orally disintegrating tablets (ODTs) containing Ibuprofen granules prepared by hot melt extrusion, Colloids and Surfaces B: Biointerfaces. 86 (2011).

DOI: 10.1016/j.colsurfb.2011.04.007

[9] Y. Okuda, Y. Irisawa, K. Okimoto, et al., A new formulation for orally disintegrating tablets using a suspension spray-coating method, International Journal of Pharmaceutics. 382 (2009) 80–87.

DOI: 10.1016/j.ijpharm.2009.08.010

[10] R.M. Pabari, Z. Ramtoola, Application of face centred central composite design to optimise compression force and tablet diameter for the formulation of mechanically strong and fast disintegrating orodispersible tablets, International Journal of Pharmaceutics. 430 (2012).

DOI: 10.1016/j.ijpharm.2012.03.021

[11] S. Mehta, T. De Beer, J.P. Remon, et al., Effect of disintegrants on the properties of multiparticulate tablets comprising starch pellets and excipient granules. Int. J. Pharm. 422 (2012) 310–317.

DOI: 10.1016/j.ijpharm.2011.11.017

[12] A. Hegedus, K. Pintye-Hodi, Comparison of the effects of different drying techniques on properties of granules and tablets made on a production scale, Int. J. Pharm. 330 (2007) 99–104.

DOI: 10.1016/j.ijpharm.2006.09.001

[13] F. AlHusban, Y. Perrie, A.R. Mohammed, Formulation of multiparticulate systems as lyophilised orally disintegrating tablets, Europ. J. Pharmaceutics and Biopharmaceutics. 79 (2011) 627–634.

DOI: 10.1016/j.ejpb.2011.05.014

[14] S.P. Simonaho, T.A. Takala, M. Kuosmanen, J. Ketolainen, Ultrasound transmission measurements for tensile strength evaluation of tablets, Int. J. Pharm. 409 (2011) 104–110.

DOI: 10.1016/j.ijpharm.2011.02.033

[15] P. García-Triñanes, M. Bao, J.J. Casares, T. Ittershagen, M. Morgeneyer, Study on the mechanical strength of primary carbonate tablets, Powder Technology. 204 (2010) 124–130.

DOI: 10.1016/j.powtec.2010.07.027

[16] F. Fichtner, A.C. Rasmuson, E.M. Alander, et al., Effect of preparation method on compactability of paracetamol granules and agglomerates, Int. J. Pharmaceutics. 336 (2007) 148–158.

DOI: 10.1016/j.ijpharm.2006.11.046

[17] M.G. Herting, P. Kleinebudde, Studies on the reduction of tensile strength of tablets after roll compaction/dry granulation, Europ. J. Pharm. Biopharm. 70 (2008) 372–379.

DOI: 10.1016/j.ejpb.2008.04.003

[18] J. Vercruysse, D.C. Díaz, E. Peeters, et al., Continuous twin screw granulation: Influence of process variables on granule and tablet quality, Europ. J. Pharm. Biopharm. 82 (2012) 205–211.

DOI: 10.1016/j.ejpb.2012.05.010

[19] L. Farber, K.P. Hapgood, J.N. Michaels, et al., Unified compaction curve model for tensile strength of tablets made by roller compaction and direct compression, Int. J. Pharm. 346 (2008) 17–24.

DOI: 10.1016/j.ijpharm.2007.06.022

[20] M. Dumarey, H. Wikström, M. Fransson, et al., Combining experimental design and orthogonal projections to latent structures to study the influence of microcrystalline cellulose properties on roll compaction, International Journal of Pharmaceutics. 416 (2011).

DOI: 10.1016/j.ijpharm.2011.06.018

[21] N. Kottala, A. Abebe, O. Sprockel, et al., Influence of compaction properties and interfacial topography on the performance of bilayer tablets, Int. J. Pharmaceutics. 436 (2012) 171–178.

DOI: 10.1016/j.ijpharm.2012.05.026

[22] A. Siddiqui, S. Nazzal, Measurement of surface color as an expedient QC method for the detection of deviations in tablet hardness, International Journal of Pharmaceutics. 341 (2007) 173–180.

DOI: 10.1016/j.ijpharm.2007.04.006

[23] S. Lakio, S. Siiriä, H. Räikkönen, et al., New insights into segregation during tabletting, International Journal of Pharmaceutics. 397 (2010) 19–26.

DOI: 10.1016/j.ijpharm.2010.06.041

[24] Z. Rahman, A.S. Zidan, M.A. Khan, Risperidone solid dispersion for orally disintegrating tablet: Its formulation design and non-destructive methods of evaluation, Int. J. Pharm. 400 (2010) 49–58.

DOI: 10.1016/j.ijpharm.2010.08.025

[25] I. Akseli, C. Cetinkaya, Air-coupled non-contact mechanical property determination of drug tablets, International Journal of Pharmaceutics. 359 (2008) 25–34.

DOI: 10.1016/j.ijpharm.2008.03.020