Tailoring of Bone Scaffold Properties Using Silicate/Phosphate Glass Mixtures

Giorgia Novajra; Polytimi Perdika; Roberto Pisano; Francesco Baino; Julian R. Jones; Aldo Roberto Boccaccini; Rainer Detsch; Chiara Vitale-Brovarone

doi:10.4028/www.scientific.net/KEM.631.283

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HomeKey Engineering MaterialsKey Engineering Materials Vol. 631Tailoring of Bone Scaffold Properties Using...

Tailoring of Bone Scaffold Properties Using Silicate/Phosphate Glass Mixtures

Abstract:

Different ratios of a resorbable phosphate glass (ICEL) and a bioactive silicate glass (CEL2) were co-sintered to obtain 3D porous scaffolds by gel-cast foaming method. The scaffold morphology, crystalline phases and compressive strength were studied. All the scaffolds showed a 3D structure with highly interconnected pores. The ICEL/CEL2 co-sintering resulted in a lower shrinkage leading to higher scaffold porosity (more than 70 vol%) compared to pure ICEL and CEL2 (about 65 vol%). Tuning ICEL/CEL2 ratio allowed the modulation of the scaffold resorption rate, with weight loss ranging from 20% to 75% after soaking for 3 months in simulated body fluid. Scaffolds containing higher amount of CEL2 silicate glass, resulted in a very high bioactivity. In vitro biological test showed no toxic effect of the scaffolds on human osteoblast-like cells.

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Periodical:

Key Engineering Materials (Volume 631)

Pages:

283-288

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.631.283

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Online since:

November 2014

Authors:

Giorgia Novajra, Polytimi Perdika, Roberto Pisano, Francesco Baino, Julian R. Jones, Aldo Roberto Boccaccini, Rainer Detsch, Chiara Vitale-Brovarone

Keywords:

Bone Scaffold, Co-Sintering, Gel-Cast Foaming, Phosphate Glass, Silicate Glass

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