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HomeKey Engineering MaterialsKey Engineering Materials Vol. 633Influence of Mixing Environmental Conditions on...

Influence of Mixing Environmental Conditions on Flowability of Lactose Blends

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Abstract:

Powder flowability is one of the most important properties affecting the filling and delivering processes of dry powder inhalations. When the powder is exposed to different environmental (temperature, relative humidity (RH)) conditions, the interaction between particulates would influence the flowability of powders. Blends of 83% coarse lactose (D₅₀ =126μm) and 17% fine lactose (D₅₀ = 7μm) were prepared at three different mixing environments and the effects of temperature and humidity on powder flowability were investigated. Results indicated that mixing under relatively higher temperature and lower RH environmental conditions improved the flowability of lactose blends.

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Periodical:

Key Engineering Materials (Volume 633)

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3-6

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.633.3

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Online since:

November 2014

Authors:

Xiang Yun Lu*, Lan Chen, Rui Lin Heng, Yun Zhang Cheng, Umezuruike Linus Opara

Keywords:

Flowability, Lactose Blend, Relative Humidity

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© 2015 Trans Tech Publications Ltd. All Rights Reserved

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