Hyaluronic Acid - Innovative Therapeutic Principle

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The article presents the experience of a new therapeutic method, addressing postoperative implant pathology.Methods: Hyaluronic acid has been used in the management of various mucoperiosteal pathologies (directing secondary healing of oral wounds, restoration / increasing the volume of connective tissue – periosteal preoperativ or the papillary volume).Hyaluronic acid used had different concentration. The presentation forms both viscous and fluid particle size and type/acid’s grade of complexation) provided various therapeutic effects with specific indication of administration respected by the authors. Different products available at this time in Romania were used analyzing the results in time.Results: This therapeutic approach provided a good management in secondary granulation and wound healing of oral tissues in difficult cases (GBR, implant therapy) in which the persistence of dehiscence wound can cause a failure of surgical treatment (loss of membrane, alloplastic material or implant).Conclusion: This results places this innovative therapeutic method with others successful therapeutic solutions in usual dental practice, providing a quick and efficient settlement of some difficult clinical cases.

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41-45

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May 2016

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© 2016 Trans Tech Publications Ltd. All Rights Reserved

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[1] M.E. Adams, M.H. Atkinson, A.J. Lussier, J.I. Schulz, K.A. Siminovitch, J.P. Wade, et al, The role of viscosupplementation with hylan G-F 20 (Synvisc) in the treatment of osteoarthritis of the knee: A Canadian multicenter trial comparing hylan G-F 20 alone, hylan G-F 20 with non-steroidal anti-inflammatory drugs (NSAIDs) and NSAIDs alone, Osteoarthritis Cartilage 3(1995).

DOI: 10.1016/s1063-4584(05)80013-5

Google Scholar

[2] T. Neumayer, A. Prinz, O. Findl, Effect of a new cohesive ophthalmic viscosurgical device on corneal protection and intraocular pressure in small-incision cataract surgery, J Cataract Refract Surg, 34(2008) 1362-6.

DOI: 10.1016/j.jcrs.2008.04.018

Google Scholar

[3] F.S. Brandt, A. Cazzaniga, Hyaluronic acid gel fillers in the management of facial aging, Clin Interv Aging, 3(2008) 153-159.

DOI: 10.2147/cia.s2135

Google Scholar

[4] I.C. Stirbu, A.C. Fasui, S.M. Popescu, D. Iorgulescu, V. Mercut, Hyaluronic acid – innovative therapeutic method for gingival interdental papilla reconstruction, Current Health Sciences Journal, suppl 10 (2014) 56-59.

Google Scholar

[5] A. Pagnacco, R. Vangelisti, C. Erra, A. Poma, Double-blind clinical trial versus placebo of a new sodium-hyaluronate- based gingival gel, Attualita Terapeutica Internazionale, 15(1997) 1-7.

Google Scholar

[6] D. Scharnweber, L. Hübner, S. Rother, U. Hempel, U. Anderegg, S.A. Samsonov, M.T. Pisabarro, L. Hofbauer, M. Schnabelrauch, S. Franz, J. Simon, V. Hintze. Glycosaminoglycan derivatives: promising candidates for the design of functional biomaterials. J Mater Sci Mater Med. 2015 Sep; 26(9): 232.

DOI: 10.1007/s10856-015-5563-7

Google Scholar

[7] U. Hempel, C. Preissler, S. Vogel, S. Moller, V. Hintze, J. Becher, et al, Artificial extracellular matrices with oversulfated glycosaminoglycan derivatives promote the differentiation of osteoblast-precursor cells and premature osteoblasts, Biomed Res Int, Article ID 938368 (2014).

DOI: 10.1155/2014/938368

Google Scholar

[8] U. Hempel, V. Hintze, S. Moller, M. Schnabelrauch, D. Scharnweber, P. Dieter, Artificial extracellular matrices composed of collagen I and sulfated hyaluronan with adsorbed transforming growth factor beta 1 promote collagen synthesis of human mesenchymal stromal cells, Acta Biomater, 8(2012).

DOI: 10.1016/j.actbio.2011.10.026

Google Scholar

[9] U. Hempel, S. Moller, C. Noack, V. Hintze, D. Scharnweber, M. Schnabelrauch, et al, Sulfated hyaluronan/collagen I matrices enhance the osteogenic differentiation of human mesenchymal stromal cells in vitro even in the absence of dexamethasone, Acta Biomater, 8(2012).

DOI: 10.1016/j.actbio.2012.06.039

Google Scholar

[10] J. Salbach, S. Kliemt, M. Rauner, T.D. Rachner, C. Goettsch, S. Kalkhof, et al, The effect of the degree of sulfation of glycosaminoglycans on osteoclast function and signaling pathways, Biomaterials, 33(2012) 8418–29.

DOI: 10.1016/j.biomaterials.2012.08.028

Google Scholar

[11] M. Schulz, P. Korn, B. Stadlinger, U. Range, S. Moller, J. Becher, et al, Coating with artificial matrices from collagen and sulfated hyaluronan influences the osseointegration of dental implants, J Mater Sci Mater Med, 25(2014) 247–58.

DOI: 10.1007/s10856-013-5066-3

Google Scholar

[12] P. Korn, M. Schulz, V. Hintze, U. Range, R. Mai, U. Eckelt, et al, Chondroitin sulfate and sulfated hyaluronan-containing collagen coatings of titanium implants influence peri-implant bone formation in a minipig model, J Biomed Mater Res A, 102(2014).

DOI: 10.1002/jbm.a.34913

Google Scholar

[13] D. Campoccia, P. Doherty, M. Radice, P. Brun, G. Abatangelo, D.F. Williams, Semisynthetic resorbable materials from hyaluronan esterification, Biomaterials, 19 (1998) 2101-2127.

DOI: 10.1016/s0142-9612(98)00042-8

Google Scholar

[14] T. Sasaki, C. Watanabe, Stimulation of osteoinduction in bone wound healing by High-molecular hyaluronic acid, Bone, 16(1995) 9-15.

DOI: 10.1016/8756-3282(95)80005-b

Google Scholar

[15] P.H. Weigel, G.M. Fuller, R.D. LeBoeuf, A model for the role of hyaluronic acid and fibrin in the early events during the inflammatory response and wound healing, J Theor Biol, 119 (1986) 219-234.

DOI: 10.1016/s0022-5193(86)80076-5

Google Scholar