Co-Deposition and Characterization of Hydroxyapatite-Chitosan and Hydroxyapatite-Polyvinylacetate Coatings on 304 SS for Biomedical Devices

Abstract:

During the last decades, biomaterials have been deeply studied to perform and improve coatings for biomedical devices. Metallic materials, especially in the orthopedic field, represent the most common material used for different type of devices thanks to their good mechanical properties. Nevertheless, low/medium resistance to corrosion and low osteointegration ability characterizes these materials. To overcome these problems, the use of biocoatings on metals substrate is largely diffused. In fact, biocoatings have a key role to confer biocompatibility properties, to inhibit corrosion and thus improve the lifetime of implanted devices. In this work, the attention was focused on Hydroxyapatite-Chitosan (HA/CS) and Hydroxyapatite-Polyvinylacetate (HA/PVAc) composites, that have been studied as biocoatings for 304 SS based devices. Hydroxyapatite was selected for its osteoconductivity thanks to its chemical structure similar to bones. Furthermore, Chitosan and Polyvinylacetate are largely used yet in medical field (e.g. antibacterial agent or drug deliver) and in this work were used to create a synergic interaction with hydroxyapatite to increase the strength and bioactivity of coating. Biocotings were obtained by galvanic deposition process that does not require an external power supply. It is a spontaneous electrochemical deposition in which materials with different standard electrochemical potential were short-circuited and immersed in an electrolytic solution. Electrons supply for the cathodic reaction in the noblest material comes from oxidation of the less noble material. SEM, EDS, XRD and RAMAN were performed for chemical-physics characterization of biocoatings. Polarization and impedance measurements have been carried out to evaluate corrosion behavior. Besides, in-vitro cytotoxicity assays have been done for the biological features.

• Periodical: Key Engineering Materials (Volume 813)
• Pages: 153-158
• DOI: https://doi.org/10.4028/www.scientific.net/KEM.813.153
• Online since: July 2019
• Authors: Claudio Zanca*, Isabella Mendolia, Elisa Capuana, Giuseppe Blanda, Francesco Carfì Pavia, Valerio Brucato, Giulio Ghersi, Vincenzo la Carrubba, Salvatore Piazza, Carmelo Sunseri, Rosalinda Inguanta
• Keywords: 304 Stainless Steel, Chitosan, Corrosion, Cytocompatibility, Galvanic Deposition, Hydroxyapatite, Orthopedic Implants, Polyvinyl Acetate

References

[1] B. Zhang, D. Myers, G. Wallace, M. Brandt, P. Choong, Bioactive coatings for orthopaedic implants. Recent trends in development of implant coatings, Int. J. Mol. Sci. 15 (2014) 11878-11921.

DOI: 10.3390/ijms150711878

[2] R. Manonmani, S. P. Vinodhini, B. Venkatachalapathy, T. M. Sridhar, Electrochemical, mechanical and osseointegration evaluation of NBPC-coated 316L SS by EPD, Surf. Eng. 34 (2018) 511-519.

DOI: 10.1080/02670844.2017.1341224

[3] N. Eliaz, T. M. Sridhar, U. Kamachi Mudali, B. Raj, Electrochemical and electrophoretic deposition of hydroxyapatite for orthopaedic applications, Surf. Eng. 21 (2005) 238-242.

DOI: 10.1179/174329405x50091

[4] A. Jankovic, S. Erakovic, M. Mitric, Z. D. Juranic, G. C. P. Tsui, C-Y. Tang,V. Miskovic-Stancovic, K. Y. Rhee, and S. J. Park, Bioactive hydroxyapatite/graphene composite coating and its corrosion stability in simulated body fluid, J. All. Comp., 624 (2015) 148-157.

DOI: 10.1016/j.jallcom.2014.11.078

[5] R. A. Nogueira, L. M. C. Pinto, A. C. D. Angelo, A. P. R. A. Claro, and C. R. Grandini, Interstitial Oxygen's Influence on the Corrosion Behavior of Ti-9Mo Alloys, Mat. Res., 16 (2013) 1398-1404.

DOI: 10.1590/s1516-14392013005000134

[6] D. Elieh-Ali-Komi, M. R. Hamblin, Chitin and chitosan: production and application of versatile biomedical nanomaterials. Int. J. Adv. Res., 4 (2016) 411-427.

[7] A. Samide, G. Brătulescu, C. Merişanu, N. Cioateră, Anticorrosive coating based on poly (vinyl acetate) formed by electropolymerization on the copper surface, J. Appl. Polym. Sci., 136 (2019) 47320.

DOI: 10.1002/app.47320

[8] G. Blanda, V. Brucato, F. Carfì Pavia, S. Greco, S. Piazza, C. Sunseri, R. Inguanta, R., Galvanic deposition and characterization of brushite/hydroxyapatite coatings on 316L stainless steel, Mater. Sci. Eng. C, 64 (2016) 93-101.

DOI: 10.1016/j.msec.2016.03.088

[9] G. Blanda, V. Brucato, F. Carfì Pavia, S. Greco, S. Piazza, C. Sunseri, R. Inguanta In Vitro Corrosion and Biocompatibility of Brushite/Hydroxyapatite Coatings Obtained by Galvanic Deposition on 316LSS. J. Electrochem. Soc., 165 (2018) G1-G10.

DOI: 10.1149/2.0391802jes

[10] G. Blanda, V. Brucato, F.Carfì Pavia, G. Conoscenti, V. La Carrubba, S. Piazza, C. Sunseri, R. Inguanta, Chitosan-coating deposition via galvanic coupling, ACS Biomater. Sci. Eng., 5 (2019) 1715-1724.

DOI: 10.1021/acsbiomaterials.8b01548