Optimization of Boesenbergia rotunda Extract-Loaded Polyvinyl Alcohol Hydrogel Wound Dressing by Box-Behnken Design

Pattaranut Eakwaropas; Yin Yin Myat; Tanasait  Ngawhirunpat; Theerasak Rojanarata; Prasopchai Patrojanasophon; Prasert Akkaramongkolporn; Praneet Opanasopit

doi:10.4028/www.scientific.net/KEM.819.38

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HomeKey Engineering MaterialsKey Engineering Materials Vol. 819Optimization of Boesenbergia rotunda...

Optimization of Boesenbergia rotunda Extract-Loaded Polyvinyl Alcohol Hydrogel Wound Dressing by Box-Behnken Design

Abstract:

The objective of this study was to optimize fabrication variables that affected desirable properties of dressings. Boesenbergia rotunda extract incorporated PVA hydrogels for wound dressings were fabricated by freeze-thaw method. The fabrication variables including PVA concentration (15, 17.5 and 20 % w/w), freeze-thaw cycle (2, 3 and 4 cycles) and extract loading (30, 40 and 50 % w/w) were studied and optimized. Effects of variables on the hydrogel wound dressing properties were determined by using Box-Behnken design and response surface method. Hydrogel properties such as tensile strength, elongation at break, Young’s Modulus, water content, swelling and erosion were measured and used as the designed responses. From statistical data analysis (p <0.05), the polynomial quadratic equation which indicated the significant effects of fabrication variables on the hydrogel properties was generated. In conclusion, desirable B. rotunda extract loaded PVA hydrogel dressing was favorably designed. The optimized PVA concentration, freeze-thaw cycle and extract loading were 17.07 % w/w, 3.86 cycles and 50 % w/w, respectively.

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Periodical:

Key Engineering Materials (Volume 819)

Pages:

38-44

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.819.38

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Online since:

August 2019

Authors:

Pattaranut Eakwaropas, Yin Yin Myat, Tanasait Ngawhirunpat, Theerasak Rojanarata, Prasopchai Patrojanasophon, Prasert Akkaramongkolporn, Praneet Opanasopit*

Keywords:

Box-Behnken Design, Freeze-Thawing, Hydrogel Dressing, Poly(Vinyl Alcohol) (PVA)

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