Key Engineering Materials Vol. 854

Abstract: Dogs underwent high-frequency automated tibia lengthening with the Ilizarov apparatus over a 1.8-mm hydroxyapatite-coated intramedullary titanium wire. Daily distraction was 3.0 mm with a fraction of 0.125 mm/h and continued ten days. The regenerate was well vascularized, had zonal structure and was of normal or hyperplastic type to the end of distraction. Osteogenesis was fast and complete. The wire served for both mechanical and biological reinforcement of the bone callus and provided reduction of external fixation time. Mean consolidation time with the apparatus on the limb was 13.83±4.02 days. Overall, external fixation index was 10.5 days/cm and 4.8 days/cm in the consolidation phase.

Abstract: The search for effective antioxidants is an urgent medical and scientific problem, since oxidative stress causes a number of diseases and accelerates aging of human body. In this paper, we analyzed the ability of a new water-soluble fullerene C70 (F350) derivative to bind reactive oxygen species (ROS) when it was added to human embryonic lung fibroblasts (HELF). We found its non-toxic concentrations for cells, since the fullerene derivatives biosafety assessment is important for the potential application of the nanocomposites in medicine and biology. We also investigated the ability of this fullerene derivative to pass the cell membrane.