Development and Evaluation of Astaxanthin Orally Disintegrating Tablets Prepared from Coprocessed Excipients for Use in the Elderly

Abstract:

The world’s population is aging; therefore, conventional pharmaceutical dosage forms designed for adult are not suitable. Orally disintegrating tablets (ODTs) are innovative dosage forms designed to overcome the problem of difficulty in swallowing or dysphagia, which is a common problem among all age groups, especially the elderly. This study aimed to develop and assess ODTs loaded with astaxanthin and manufactured by direct compression method using different coprocessed pharmaceutical excipients, including F-Melt^® Type C, F-Melt^® Type M, and Pearlitol Flash^®. The results found that the ODTs prepared from F-Melt^® Type C and F-Melt^® Type M offered better mechanical properties. An astaxanthin concentration of 20–40 mg in the tablets did not retard the disintegration mechanism. From the taste modified formulation, the tablets disintegrated within 82 seconds. The tablet hardness was higher than 35.33 N and its friability was less than 0.5%. Lastly, active ingredient dissolved more than 80% in 2 minutes.

• Periodical: Key Engineering Materials (Volume 859)
• Pages: 295-300
• DOI: https://doi.org/10.4028/www.scientific.net/KEM.859.295
• Online since: August 2020
• Authors: Tanikan Sangnim, Kampanart Huanbutta*
• Keywords: Aging Population, Astaxanthin, Coprocessed Pharmaceutical Excipients, Oral Disintegrating Tablets

References

[1] M.P.S. Heller, Is Asia prepared for an aging population?, International Monetary Fund, (2006).

[2] B.N. Ames, M.K. Shigenaga, T.M. Hagen, Oxidants, antioxidants, and the degenerative diseases of aging, Proc. Natl. Acad. Sci. USA. 90 (1993) 7915-7922.

DOI: 10.1073/pnas.90.17.7915

[3] J. Igielska-Kalwat, J. Gościańska, I. Nowak, Carotenoids as natural antioxidants, Postepy Hig. Med. Dosw. (Online). 69 (2015) 418-428.

DOI: 10.5604/17322693.1148335

[4] R.G. Fassett, J.S. Coombes, Astaxanthin: a potential therapeutic agent in cardiovascular disease, Mar. Drugs. 9 (2011) 447-465.

DOI: 10.3390/md9030447

[5] J.P. Yuan, J. Peng, K. Yin, J.H. Wang, Potential health promoting effects of astaxanthin: a high value carotenoid mostly from microalgae, Mol. Nutr. Food Res. 55 (2011) 150-165.

DOI: 10.1002/mnfr.201000414

[6] K. Huanbutta, A. Yunsir, P. Sriamornsak, T. Sangnim, Development and in vitro/in vivo evaluation of tamarind seed gum-based oral disintegrating tablets after fabrication by freeze drying, J. Drug Deliv. Sci. Technol. 54 (2019) 101298.

DOI: 10.1016/j.jddst.2019.101298

[7] N. Garg, H. Dureja, D. Kaushik, Co-processed excipients: A patent review, Recent Pat. Drug Deliv. Formul. 7 (2013) 73-83.

DOI: 10.2174/187221113804805847

[8] K. Huanbutta, M.F. Asmani, A. Yugesvaran, L. Vedewellu, T. Sangnim, Development and evaluation of diclofenac sodium oral dispersible tablet (ODT) formulation using different types of co-excipients, Isan J. Pharm. Sci. 14 (2018) 45-57.

[9] P. Nagar, K. Singh, I. Chauhan, M. Verma, M. Yasir, A. Khan, R. Sharma, N. Gupta, Orally disintegrating tablets: formulation, preparation techniques and evaluation, J. Appl. Pharm. Sci. 1 (2011) 35-45.

[10] A. Guyot-Hermann, D.J. Ringard, Disintegration mechanisms of tablets containing starches. Hypothesis about the particle-particle repulsive force, Drug Dev. Ind. Pharm. 7 (1981) 155-177.

DOI: 10.3109/03639048109057708

[11] R.R. Ambati, S.M. Phang, S. Ravi, R.G. Aswathanarayana, Astaxanthin: sources, extraction, stability, biological activities and its commercial applications—a review, Mar. Drugs. 12 (2014) 128-152.

DOI: 10.3390/md12010128

[12] M.J. Qureshi, C. Mallikarjun, W.G. Kian, Enhancement of solubility and therapeutic potential of poorly soluble lovastatin by SMEDDS formulation adsorbed on directly compressed spray dried magnesium aluminometasilicate liquid loadable tablets: a study in diet induced hyperlipidemic rabbits, Asian J. Pharm. Sci. 10 (2015) 40-56.

DOI: 10.1016/j.ajps.2014.08.003

[13] Y. Nakai, E. Fukuoka, S. Nakajima, J. Hasegawa, Crystallinity and physical characteristics of microcrystalline cellulose, Chem. Pharm. Bull. 25 (1977) 96-101.

DOI: 10.1248/cpb.25.96

[14] M. Fujii, H. Okada, Y. Shibata, H. Teramachi, M. Kondoh, Y. Watanabe, Preparation, characterization, and tableting of a solid dispersion of indomethacin with crospovidone, Int. J. Pharm. 293 (2005) 145-153.

DOI: 10.1016/j.ijpharm.2004.12.018

[15] S.A. Adebayo, E. Brown-Myrie, O.A. Itiola, Comparative disintegrant activities of breadfruit starch and official corn starch, Powder technol. 181 (2008) 98-103.

DOI: 10.1016/j.powtec.2006.12.013