Fabrication and Characterization of Alginate/Iron (III) Oxide Beads and Biofilm for Biomedical Applications

Abstract:

This research study focused on the fabrication and characterization of sodium alginate incorporated with iron (III) oxide in the form of beads and biofilm for biomedical application. The fabrication of the samples was carried out by using solution casting method and syringe pump extrusion technique. Beads and biofilm of sodium alginate incorporated with iron oxide were characterized by several characterization testing such as XRD, FTIR and contact angle measurement. From the XRD testing shows the diffraction peak that confirmed the cubic structure of Maghemite. Then, FTIR analysis shows the presence of several intermolecular and intramolecular bond stretching of sodium alginate. Lastly, contact angle measurement exhibits that alginate incorporated with iron oxide has hydrophilic behavior due to the contact angle less than 90Also, it was found that as the contact angle reduced as the weight of iron oxide increased.

• Periodical: Key Engineering Materials (Volume 908)
• Pages: 177-182
• DOI: https://doi.org/10.4028/p-3z7053
• Online since: January 2022
• Authors: Wan Ahmad Mustaqim Ahmad Zakhi*, Maizlinda Izwana Idris
• Keywords: Beads, Contact Angle, Fourier Transform Infrared Spectroscopy, Iron Oxide, Sodium Alginate, X-Ray Diffusion

References

[1] R. Subbiah, P. Du, M. P. Hwang, I. G. Kim, S. Y. Van, Y. K. Noh, Dual Growth Factor-Loaded Core-Shell Polymer Microcapsules Can Promote Osteogenesis and Angiogenesis, 22 (2014) 1320–1329.

DOI: 10.1007/s13233-014-2183-x

[2] M. A. Morales, P. V. Finotellia, J. A. H. Coaquira, M. H. M. Rocha-Leão, C. Diaz-Aguila, E. M. Baggio-Saitovitch, A. M. Rossi, In situ synthesis and magnetic studies of iron oxide nanoparticles in calcium-alginate matrix for biomedical applications, Mater. Sci. Eng. C 28 (2008) 253–257.

DOI: 10.1016/j.msec.2006.12.016

[3] L. Gasperini, D. Maniglio, C. Migliaresi, Microencapsulation of cells in alginate through an electrohydrodynamic process, J. Bioact. Compat. Polym. 28 (2013) 413-425.

DOI: 10.1177/0883911513501599

[4] M. J. Kang, I. Y. Oh, B. C. Choi, B. K. Kwak, J. Lee, Y. W. Choi, Development of superparamagnetic iron oxide nanoparticles (SPIOs)-embedded chitosan microspheres for Magnetic Resonance (MR)-traceable embolotherapy, Biomol. Ther. 17 (2009) 98–103.

DOI: 10.4062/biomolther.2009.17.1.98

[5] S. Laurent, M. Mahmoudi, Superparamagnetic iron oxide nanoparticles: Promises for diagnosis and treatment of cancer, Int. J. Mol. Epidemiol. Genet. 2 (2011) 367–390.

[6] A. S. Lübbe, C. Bergemann, H. Riess, F. Schriever, P. Reichardt, K. Possinger, M. Matthias, B. Dörken, F. Herrmann, R. Gürtler, P. Hohenberger, N. Haas, R. Sohr, B. Sander, A. Lemke, D. Ohlendorf, W. Huhnt, D. Huhn, Clinical experiences with magnetic drug targeting: A phase I study with 4'-epidoxorubicin in 14 patients with advanced solid tumors, Cancer Res. 56 (1996) 4686–4693.

[7] D. Rana, M. Ramalingam, RSC Advances carriers for stem cell delivery : preparation and characterization, RSC Adv. 6 (2016) 20475–20484.

DOI: 10.1039/c5ra26447b

[8] C. H. Goh, P. Wan, S. Heng, L. W. Chan, Alginates as a useful natural polymer for microencapsulation and therapeutic applications, Carbohydr. Polym. 88 (2012) 1–12.

DOI: 10.1016/j.carbpol.2011.11.012

[9] O. Philippova, A. Barabanova, V. Molchanov, A. Khokhlov, Magnetic polymer beads: Recent trends and developments in synthetic design and applications, Eur. Polym. J. 47 (2011) 542–559.

DOI: 10.1016/j.eurpolymj.2010.11.006

[10] F. Lin, K. C. Wu, Functionalized magnetic iron oxide / alginate core- shell nanoparticles for targeting hyperthermia, (2015) 3315–3328.

DOI: 10.2147/ijn.s68719

[11] G. Dudek, R. Turczyn, D. Djurado, Collation efficiency of poly(vinyl alcohol) and alginate membranes with iron-based magnetic organic/inorganic fillers in pervaporative dehydration of ethanol, Materials (Basel). 13 (2020).

DOI: 10.3390/ma13184152

[12] M. Blue, C. Li, J. Lu, S. Li, Y. Tong, B. Ye, Synthesis of Magnetic Microspheres with Sodium Alginate and Activated Carbon for Removal of Methylene Blue, Materials 10 (2017) 84.

DOI: 10.3390/ma10010084

[13] P. M. Kulal, D. P. Dubal, C. D. Lokhande, V. J. Fulari, Chemical synthesis of Fe2O3 thin films for supercapacitor application, J. Alloys Compd. 509 (2011) 2567–2571.

DOI: 10.1016/j.jallcom.2010.11.091