Surface Enhancement of Magnesium Implants for Long Term Applications

Abstract:

Mg is a biodegradable metal that possesses excellent biocompatibility, bioactivity, nontoxic degradation products, and unique mechanical properties. These characteristics make it an attractive element to be used as implant material in physiological environments because it biodegrades and has excellent biocompatibility and bioactivity. In addition, an excess of magnesium ions does not result in cellular toxicity in the human body, where it is often getting rid along with urine. The most significant disadvantage of magnesium is its uncontrolled quick corrosion rate, which can cause rapid loss in mechanical qualities. As a consequence, this might cause the implant to fail before the tissue has completely healed.The purpose of this research is to improve the surface features of the implant, as well as to control the rate at which magnesium corrodes and, as a result, the concentration of magnesium ions that are released into the surrounding environment. This will be accomplished by coating the implant surface with a composite biodegradable polymer (Polycaprolactone PCL) matrix reinforced with MgO Nano-particles which will act as a protective layer to increase the corrosion resistance of magnesium implants. In addition, a laser surface modification procedure was implemented in order to improve the surface's qualities and make certain that there is a strong adhesion between the coating and the surface of the substrate. In order to increase the surface roughness of the specimen, (Nd: YAG) laser device was utilized to create pulses on the surface of the specimen.

• Periodical: Key Engineering Materials (Volume 937)
• Pages: 79-87
• DOI: https://doi.org/10.4028/p-l74381
• Online since: December 2022
• Authors: Amna Al-Janabi*, Fatima J. Alhasani, Emad S. Al Hassani
• Keywords: Biodegradable Magnesium, Biomaterials, Laser Surface Modification, Polymeric Coating

References

[1] Witte F, Kaese V, Haferkamp H, et al. In vivo corrosion of four magnesium alloys and the associated bone response Biomaterials, 2005, 26(17): 3557–3563.

DOI: 10.1016/j.biomaterials.2004.09.049

[2] Witte F, Fischer J, Nellesen J, et al. In vitro and in vivo corrosion measurements of magnesium alloy biomaterials, 2006, 27(7):1013–1018.

DOI: 10.1016/j.biomaterials.2005.07.037

[3] W. Wang, Y.L. Wang, M. Chen, L. Chen, J. Zhang, Y.D. Li, M.H. Li, G.Y. Yuan, Magnesium alloy covered stent for treatment of a lateral aneurysm model in rabbit common carotid artery: An in vivo study, Sci. Rep. 6 (2016) 37401.

DOI: 10.1038/srep37401

[4] N.T. Kirkland, J. Lespagnol, N. Birbilis, M.P. Staiger, A survey of bio-corrosion rates of magnesium alloys, Corros. Sci. 52(2010) 287-291.

DOI: 10.1016/j.corsci.2009.09.033

[5] L.Y. Li, B. Liu, R.C. Zeng, S.Q. Li, F. Zhang, Y.H. Zou, H.G. Jiang, X.B. Chen, S.K. Guan, Q.Y. Liu, In vitro corrosion of magnesium alloy AZ31 — a synergetic influence of glucose and Tris, Front. Material Science 12 (2018) 184-197.

DOI: 10.1007/s11706-018-0424-1

[6] K. Rezwan, Q.Z. Chen, J.J. Blaker, A.R. Boccaccini, Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering, Biomaterials. 27 (2006) 3413-3431.

DOI: 10.1016/j.biomaterials.2006.01.039

[7] J. Sun, Y. Zhu, L. Meng, P. Chen, T. Shi, X. Liu, Y. Zheng, Electrophoretic deposition of colloidal particles on Mg with cytocompatibility, antibacterial performance, and corrosion resistance, Acta Biomaterial. 45 (2016) 387-398.

DOI: 10.1016/j.actbio.2016.09.007

[8] J. Blacklock, T.K. Sievers, H. Handa, Y.Z. You, D. Oupický, G. Mao, H. Möhwald, Cross-linked bioreducible layer-by-layer films for increased cell adhesion and transgene expression, J. Phys. Chem. B. 114 (2010) 5283-5291.

DOI: 10.1021/jp100486h

[9] S.R. Chastain, A.K. Kundu, S. Dhar, J.W. Calvert, A.J. Putnam, Adhesion of Mesenchymal Stem Cells to Polymer Scaffolds Occurs Via Distinct ECM Ligands and Controls their Osteogenic Differentiation, (2006).

DOI: 10.1002/jbm.a.30686

[10] X. Xin, M. Hussain, J.J.M. Ã, Continuing Differentiation of Human Mesenchymal Stem Cells and Induced Chondrogenic and Osteogenic Lineages in Electrospun PLGA Nanofiber Scaffold, 28 (2007) 316–325.

DOI: 10.1016/j.biomaterials.2006.08.042

[11] E. Malikmammadov, T.E. Tanir, A. Kiziltay, V. Hasirci, N. Hasirci PCL and PCL-based Materials in Biomedical Applications Taylor & Francis (2018).

DOI: 10.1080/09205063.2017.1394711

[12] L. Gritsch, L. Liverani, C. Lovell, and A. R. Boccaccini, Polycaprolactone Electrospun Fiber Mats Prepared Using Benign Solvents: Blending with Copper(II)-Chitosan Increases the Secretion of Vascular Endothelial Growth Factor in a Bone Marrow Stromal Cell Line,, Macromol. Biosci., vol. 20, no. 3, 2020,.

DOI: 10.1002/mabi.201900355

[13] M. A. Woodruff and D. W. Hutmacher, The return of a forgotten polymer - Polycaprolactone in the 21st century,, Prog. Polym. Sci., vol. 35, no. 10, p.1217–1256, 2010,.

DOI: 10.1016/j.progpolymsci.2010.04.002