Effects of Hydrophilicity/Hydrophobicity of a Drug on its Release from PLGA Films

Abstract:

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Hydrophilic ciprofloxacin hydrochloride and hydrophobic sirolimus were used as model drugs, and poly(dl-lactic-co-glycolic acid) 50/50 (PLGA 50/50) was used as the drug carrier to investigate the effects of hydrophilicity/hydrophobicity of a drug on its release properties from PLGA films. The results showed that ciprofloxacin hydrochloride induced faster release curves than sirolimus, and it also promoted the weight loss of films, while sirolimus inhibited the weight loss of films. However, both drugs inhibited the degradation of biodegradable carrier.

Info:

Periodical:

Materials Science Forum (Volumes 675-677)

Edited by:

Yi Tan and Dongying Ju

Pages:

369-372

DOI:

10.4028/www.scientific.net/MSF.675-677.369

Citation:

H. Z. Liu et al., "Effects of Hydrophilicity/Hydrophobicity of a Drug on its Release from PLGA Films", Materials Science Forum, Vols. 675-677, pp. 369-372, 2011

Online since:

February 2011

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$35.00

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