Effects of Hydrophilicity/Hydrophobicity of a Drug on its Release from PLGA Films

Hong Ze Liu; Min Qi; Bo Guo; Hui Hua Liu

doi:10.4028/www.scientific.net/MSF.675-677.369

Paper Titles

TiO_x Film Formation on NiTi Alloy (100) Surface: Density Functional Theory Investigation
p.353

Composites of Poly(lactic Acid) with Rice Straw Fibers Modified by Poly(butyl Acrylate)
p.357

Study on the Application of Silane Coupling Agent in Rice Straw/Poly(butylene Succinate) Composites
p.361

Structure Characteristics of the Hemifusus tuba Conch Shell
p.365

Effects of Hydrophilicity/Hydrophobicity of a Drug on its Release from PLGA Films
p.369

Structure and CO Gas Sensing Properties of PPy/LaFeO₃ Nanocomposites
p.375

Relationship between Mechanical Properties of Modified Cementitious Composites and Properties of Polymer Films
p.379

Poly(vinyl Alcohol)/Cellulose Nanocomposite Pervaporation Membranes for Ethanol Dehydration
p.383

Investigation on Perforation Mechanism of Medium Density Polyethylene
p.387

HomeMaterials Science ForumMaterials Science Forum Vols. 675-677Effects of Hydrophilicity/Hydrophobicity of a Drug...

Effects of Hydrophilicity/Hydrophobicity of a Drug on its Release from PLGA Films

Abstract:

Hydrophilic ciprofloxacin hydrochloride and hydrophobic sirolimus were used as model drugs, and poly(dl-lactic-co-glycolic acid) 50/50 (PLGA 50/50) was used as the drug carrier to investigate the effects of hydrophilicity/hydrophobicity of a drug on its release properties from PLGA films. The results showed that ciprofloxacin hydrochloride induced faster release curves than sirolimus, and it also promoted the weight loss of films, while sirolimus inhibited the weight loss of films. However, both drugs inhibited the degradation of biodegradable carrier.

You might also be interested in these eBooks

Advanced Material Science and Technology

View Preview

Info:

Periodical:

Materials Science Forum (Volumes 675-677)

Pages:

369-372

DOI:

https://doi.org/10.4028/www.scientific.net/MSF.675-677.369

Citation:

Cite this paper

Online since:

February 2011

Authors:

Hong Ze Liu, Min Qi, Bo Guo, Hui Hua Liu

Keywords:

Degradation, Drug Release, Hydrophilicity/Hydrophobicity, Poly(dl-Lactic-Co-Glycolic Acid)

Export:

RIS, BibTeX

Price:

Permissions CCC:

Request Permissions

Permissions PLS:

Request Permissions

Сopyright:

Citation:

References

[1] Chiu L. K., Chiu W. J. and Cheng Y. L: International Journal of Pharmaceutics, Vol. 126 (1995), p.169.

Google Scholar

[2] Anderson J. M., Shive M. S: Advanced Drug Delivery Reviews Vol. 28 (1997), p.5.

Google Scholar

[3] Zolinik, B. S., Burgess D. J: Journal of Controlled Release Vol. 122 (2007), p.338.

Google Scholar

[4] Jackson J. K., Smith J. Letchford K., et al.: International Journal of Pharmaceutics Vol. 283 (2004), p.97.

Google Scholar

[5] Charlier, A., Leclerc, B., Couarraze, G.: International Journal of Pharmaceutics Vol. 200 (2000), p.115.

Google Scholar

[6] Lao. L. L., Venkatraman S.S. and Peppas N.A.: European Journal of Pharmaceutics and Biopharmaceutics Vol. 70 (2008), p.796.

Google Scholar

[7] Huang Y. Y., Venkatraman S.S., Boey F. Y. C., et al: Biomaterials Vol. 31 (2010), p.4382.

Google Scholar

[8] Alexis F., Venkatraman S.S., Rath S. K., Beoy F.: Journal of Controlled Release Vol. 98 (2004), p.67.

Google Scholar

[9] Schliecker, G., Schmidt, C., Fuchs, S., et al: International Journal of Pharmaceutics Vol. 266 (2003), p.39.

Google Scholar