Cellular Functionality on Nanotubes of Ti-30Ta Alloy

Abstract:

Recent studies have identified strong correlations between anodized metals and the production of highly biomimetic nanoscale topographies. These surfaces provide an interface of enhanced biocompatibility that exhibits a high degree of oxidation and surface energy. In this study, Human dermal fibroblasts (HDF, neonatal) were utilized to evaluate the biocompatibility of Ti-30Ta nanotubes after 1 day of culture. The anodization process was performed in an electrolyte solution containing HF (48%) and H₂SO₄ (98%) in the volumetric ratios 1:9 with the addition of 5% dimethyl sulfoxide (DMSO) at 35V for 40 min. Cellular analysis identified improved fibroblast functionality on the nanotube surface, showing increased elongation, and extracellular matrix production on the Ti-30Ta nanotubes. The results presented identify improved cellular interaction on Ti-30Ta nanotubes as compared to the control substrates. Thus, the formation of the nanotube on Ti30Ta alloy may have potential application as interface for implantable devices.

• Periodical: Materials Science Forum (Volume 805)
• Pages: 61-64
• DOI: https://doi.org/10.4028/www.scientific.net/MSF.805.61
• Online since: September 2014
• Authors: Patricia Capellato*, Barbara S. Smith, Ketul C. Popat, Ana P.R. Alves Claro
• Keywords: Human Dermal Fibroblasts, Ti-30Ta Nanotube Arrays

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