Synthesis of pH-Responsive Glycopolymer with End Group Zinc(II) Phthalocyanines as Potential Photosensitizer

Shu Guo Dong; Gui Hua Cui; Qian Duan

doi:10.4028/www.scientific.net/MSF.996.82

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HomeMaterials Science ForumMaterials Science Forum Vol. 996Synthesis of pH-Responsive Glycopolymer with End...

Synthesis of pH-Responsive Glycopolymer with End Group Zinc(II) Phthalocyanines as Potential Photosensitizer

Abstract:

A novel end-functionalized glycopolymer poly (3-O-methacryloyl-D-glucofuranose) -b-poly (2-Diethylaminoethyl Methacrylate) (PMAGlc-b-PDEA-ZnTAPc) with zinc (II) teraamaninophthalocyanine was synthesized. First, a pH-responsive copolymer PMAIpG-b-PDEA was synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization. Then PMAIpG-b-PDEA reacted with ZnTAPc and deprotected to form a water-soluble and pH-responsive photosensitizer. The structure of the PMAGlc-b-PDEA-ZnTAPc was characterized by ¹H NMR and GPC. The photophysical properties were evaluated by UV-Vis and fluorescence spectra. The PMAGlc-b-PDEA-ZnTAPc can generate singlet oxygen species with good singlet oxygen quantum yields (Φ_△=0.38), which is believed to be the major cytotoxic reactive oxygen species (ROS) for photodynamic therapy. The ZnPc functionalized glycopolymer will be used as a potential photosensitizer in the fields of photodynamic therapy.

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Periodical:

Materials Science Forum (Volume 996)

Pages:

82-87

DOI:

https://doi.org/10.4028/www.scientific.net/MSF.996.82

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Online since:

June 2020

Authors:

Shu Guo Dong*, Gui Hua Cui, Qian Duan

Keywords:

Glycopolymer, pH-Responsive, RAFT, Zinc(Ⅱ) Phthalocyanines

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