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Encapsulation of Turmeric Crude Extracted in Chitosan Hydrogel Beads for Antimicrobial in Animal Health Care Applications

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Abstract:

Hydrogel is very popular used in medicinal materials due to their properties. The aim of study is to investigate the development of chitosan (CS) hydrogel beads to extend drug-releasing time and enhance the stability of hydrogel beads from decomposition due to surrounding temperature. Gentamicin (GM) is using as a drug model for loading and releasing from hydrogel beads. For this purpose, the effects of ionic gelation of CS and tripolyphosphate (TPP) on various concentrations (1, 3, 5, and 7%w/v) are emphasized. Scanning electron microscopy (SEM) has revealed that CS hydrogel beads are roughly surface with decreasing of the %CS content. The Fourier transform infrared (FT-IR) spectra show a weak band of hydroxyl stretching at 2878 cm-1 of chitosan, the absorption band of the carbonyl stretching of the secondary amide at 1651 cm-1. The releasing solution of CS hydrogel beads exhibit an antimicrobial activity against 4 type of bacterias compared to Chloramphenical. For this reason, indicating that CS hydrogel beads are an appropriate for controlled drug release system to turmeric crude extract.

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Periodical:

Materials Science Forum (Volume 990)

Pages:

111-116

DOI:

https://doi.org/10.4028/www.scientific.net/MSF.990.111

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Online since:

May 2020

Authors:

Samitthichai Seeyangnok*, Parisa Sae-Khow, Siriporn Pranee, Kanyavee Wootitunthipong

Keywords:

Chitosan, Controlled Drug Release, Hydrogel, Turmeric Crude Extract

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© 2020 Trans Tech Publications Ltd. All Rights Reserved

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