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Synthesis of N,N,N-Trimethyl-1-Adamantyl Quaternary Ammonium Hydroxide and Technology Development

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Abstract:

N,N-dimethyl-1-adamantane was synthesized from amantadine through Eschweiler-Clarke reaction, The optimal ratio of amantadine, formic acid and formaldehyde was 1:5:4, and the reaction time was 18 h at 98°C.The product yield was 93.4% on these conditions. N,N,N-trimethyl-1-adamantyl quaternary ammonium salt then was synthesized, the product yield was 90.5%, succeeding eco-friendly procedure technology was developed. N,N,N-trimethyl-1-adamantyl quaternary ammonium hydroxide was obtained finally, target product yield was 84.3%.The structure of compounds were characterized by 1H NMR, 13C NMR, MS and GC-MS.

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Periodical:

Advanced Materials Research (Volumes 391-392)

Pages:

1159-1163

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.391-392.1159

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Online since:

December 2011

Authors:

Jian Hu, Fang Wen Yang, Ming Gang Huang

Keywords:

Adamantane, Adamantyl Quaternary Ammonium Hydroxide, Adamantyl Quaternary Ammonium Salts, Eschweiler-Clarke Reaction, Synthesis

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© 2012 Trans Tech Publications Ltd. All Rights Reserved

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