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Design and Fabrication of PDMS Microchamber for Fast Reaction Assays in Biosensing Application

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Abstract:

A simple design of a microchamber for use in reacting assays with limited sample availability has been proposed, analyzed using COMSOL 3.5 Multiphysics simulation and fabricated using soft-lithography technique . The design is based on differential pressure drop flow using capillary effect concept which has facilitated a number of interesting flow phenomena in micro-domains. For an average pressure drop of about 100/m in the setup, flow rates of bout 0.5 to 0.8 μl/s were obtained. The component a microchamber, three designs were tested (50, 70, 90 microns in width) to give a continuous open circuit flow. The system was designed and fabricated for continuous flow across sensing element where there is a requirement for low residence time due to fast reaction/diffusion rates.Also in this paper, is a sensitive and selective, also rapid, reliable, cost-effective, and suitable for in situ analysis polymer biosensor for new bio molecular approach for cancer and cancer related diseases detection at the early stage is demonstrated.

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Periodical:

Advanced Materials Research (Volume 795)

Pages:

329-333

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.795.329

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Online since:

September 2013

Authors:

Tijjani Adam, U. Hashim, M. Wesam Al-Mufti

Keywords:

Capillary, COMSOL Multiphysics, Fabrication, Micro-Channel, Micro-Fluidics, PDMS, Soft Lithography

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© 2013 Trans Tech Publications Ltd. All Rights Reserved

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References

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