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A Novel Degradation Controlled Hyaluronic Acid Derivatives

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Abstract:

A novel protocol to control the molecular degradation of hyaluronic acid (HA) was successfully developed. HA has a different conformational structure in water and in organic solvent, and the carboxyl group of HA is known to be the recognition site of CD44 and hyaluronidase. Based on these facts, HA was chemically modified in the mixed solvent of water and ethanol by grafting adipic acid dihydrazide (ADH) to the carboxyl group of HA, which resulted in high degree of ADH modification up to 85 mol% with controlled degradation of HA by hyaluronidase. The degradation controlled HA-ADH will be assessed for various tissue engineering applications.

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Advanced Biomaterials VII View Preview

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Periodical:

Key Engineering Materials (Volumes 342-343)

Pages:

525-528

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.342-343.525

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Online since:

July 2007

Authors:

Eun Ju Oh, Ji Seok Kim, Sei Kwang Hahn

Keywords:

Degradation, Derivatives, Hyaluronic Acid (HA), Hyaluronidase, Tissue Engineering

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© 2007 Trans Tech Publications Ltd. All Rights Reserved

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