Paper Titles
Glucosylated Polypropylenimine Dendrimer as a Novel Gene Carrier
p.457
Continuous Release of Protein from Biodegradable In Situ Forming Depot
p.461
Preparation of Naphthalocyanine Dendrimer Loaded Polyion Complex Micelle for Photodynamic Therapy
p.465
Enhance of Tumor Targeting by Receptor-Mediated Endocytosis Using Low Molecular Water-Soluble Chitosan Nanoparticles Loaded with Anticancer Agent
p.469
Release Profile of BSA or BDNF from Temperature Sensitive Hydrogels
p.473
Co-Precipitation of 5-Fluorouracil and Poly(L-Lactide) Using Solution-Enhanced Dispersion by Supercritical CO2
p.477
Anticoagulation and Drug Release Behavior of Curcumin-Loaded PLGA Films
p.481
Preparation and Characterization of Porous Membrane for Drug Release
p.485
Inclusion Complex Formation of Water- Soluble Drug, Captopril, and Peracetylated-β-Cyclodextrin in Supercritical CO2 for Controlled Release Applications
p.489

Release Profile of BSA or BDNF from Temperature Sensitive Hydrogels

Article Preview

Abstract:

Methoxy poly(ethylene glycol) (MPEG)-b-poly(ε-caprolactone) (PCL) diblock copolymer was synthesized by ring-opening of ε-caprolactone (ε-CL) in the presence of a monomer activator with the terminal alcohol of MPEG as an initiator. The temperature sensitive behavior of the prepared MPEG-PCL diblock copolymer solution was examined. The polymer solution formed translucent sol at the room temperature. As the temperature increased from room temperature, the sol became gel, indicating that the diblock copolymer solution at room temperature can form gel at body temperature. Brain-derived neurotrophic factor (BDNF) loaded MPEG-PCL diblock copolymer solution and Pluronic solution for comparison were prepared to examine the release behavior of BDNF. Pluronic gel exhibited nearly complete release of BDNF even at 2 day, while the release of BDNF in MPEG-PCL gel showed the prolonged release profile for 21 days. In this study, we confirmed that thermosensitive MPEG-PCL diblock copolymer in this work could utilize as a potential carrier of BDNF.

You might also be interested in these eBooks
Advanced Biomaterials VII View Preview

Info:

Periodical:

Key Engineering Materials (Volumes 342-343)

Pages:

473-476

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.342-343.473

Citation:

Cite this paper

Online since:

July 2007

Authors:

Mi Hee Cho, Hoon Hyun, Yu Na Shin, Jung Won Lee, Min Suk Lee, Hyun Hee Ahn, Moon Suk Kim, Bong Lee, Gil Son Ghang, Hai Bang Lee

Keywords:

BDNF, Hydrogel, Poly(ethylene glycol) (PEG), Poly(ε-Caprolactone), Temperature Sensitive

Export:

RIS, BibTeX

Price:

Permissions CCC:

Request Permissions

Permissions PLS:

Request Permissions

Сopyright:

© 2007 Trans Tech Publications Ltd. All Rights Reserved

Share:

Citation:

References

[1] K.B. Aubrecht, R.B. Grubbs: J. Polym. Sci. Part A: Polym. Chem. 43, 5156-5167 (2005).

Google Scholar

[2] C. Pitt, Poly(ε-caprolactone) and its copolymer. in: Chasin, M.; Langer, R. ed., Biodegradable polymers as drug delivery system. New York, Marcel Dekker, 1990, 71-120.

Google Scholar

[3] M.S. Kim, K.S. Seo, G. Khang, H.B. Lee, Macromol. Rapid Comm. 26, 643-648 (2005).

Google Scholar

[4] H.Y. Cho, H. Hyun, J.H. Lee, S.C. Jeong, I.B. Song, B. Lee, M.S. Kim, G. Khang, J.M. Rhee, H.B. Lee, Tissue Eng. Regen. Medicine 2, 368-377 (2005).

Google Scholar

[5] M.S. Kim, H. Hyun, G. Khang, H.B. Lee, Macromolecules 39, 3099-3102 (2006).

Google Scholar

[6] K.S. Seo, D.H. Keum, H. Hyun, M.S. Kim, G. Khang, H.B. Lee, Tissue Eng. Regen. Medicine 2, 109 (2005).

Google Scholar

[7] M.S. Kim, K.S. Seo, G. Khang, S.H. Cho, H.B. Lee, J. Biomed. Mater. Res. 70A, 154 (2004).

Google Scholar

[8] M.S. Kim, K.S. Seo, G. Khang, S.H. Cho, H.B. Lee, J. Polym. Sci. Part A: Polym. Chem. 42, 5784-5793 (2004).

Google Scholar

[9] M.S. Kim, H. Hyun, G. Khang, H.B. Lee, Macromolecules 39, 3099 (2006).

Google Scholar

[10] T. Katsuhiro, S. Hideki, M. Noriyoshi, H. Naohiko, M. Yoshihiro, H. Akio, Y. Horoshi, K. Hiroyuki, K. Hidemi, Tissue Eng. 11, 1618-1629 (2005).

Google Scholar