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Co-Precipitation of 5-Fluorouracil and Poly(L-Lactide) Using Solution-Enhanced Dispersion by Supercritical CO2

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Abstract:

5-Fluorouracil-poly(L-lactide) (5-Fu-PLLA) microspheres have been co-precipitated in a process namely solution-enhanced dispersion by supercritical CO2 (SEDS). First, the 5-Fu is successfully micronized and then used to produce the 5-Fu-PLLA microspheres. The 5-Fu-PLLA microspheres synthesized in the SEDS process exhibited a rather spherical shape, smooth surface, and a narrow particle size distribution, where it ranged from 531 nm to 1280 nm, with a mean particle size of 793 nm. The dichloromethane residue in the 5-Fu-PLLA microspheres is 46 ppm. The average drug load of the 5-Fu-PLLA microspheres is 12.7%. The results of this study indicate that the SEDS process is an effective technique to co-precipitate 5-Fu and PLLA as composite microspheres.

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Periodical:

Key Engineering Materials (Volumes 342-343)

Pages:

477-480

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.342-343.477

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Online since:

July 2007

Authors:

Xi Ming Pu, Yun Qing Kang, Ai Zheng Chen, Li Liao, Guang Fu Yin

Keywords:

5-Fluorouracil, Micro-Sphere, Poly(L-Lactide), Supercritical Carbon Dioxide

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© 2007 Trans Tech Publications Ltd. All Rights Reserved

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