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Synthesis and Characterization of Silica-Chitosan Porous Hybrids for Tissue Engineering

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Abstract:

A variety of types of organic polymers have been employed in the synthesis of hybrids with silica. In this work the sol-gel method was used for preparation of macroporous 3D hybrid scaffolds based on silica and chitosan in various compositions (10, 20 and 30% wt). The hybrids were analyzed by Scanning Electron Microscopy (SEM), X-ray Diffraction (DRX) and Infra-red Spectroscopy (FTIR) and the effect of addition of the polymer was evaluated. The foams obtained by sol-gel process were appropriate to produce hybrids based on chitosan-silica and showed large pore size distribution and porosity, except for hybrids with higher polymer content. The FTIR spectroscopy showed a band relative to Si-O-C bond that was also found to increase with the increasing the amounts of chitosan in the hybrid. This fact can suggest an interaction between the organic-inorganic phases in the material and provide new insights on the advantages of chitosansilica hybrid materials produced via sol-gel methodology.

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Periodical:

Key Engineering Materials (Volumes 361-363)

Pages:

967-970

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.361-363.967

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Online since:

November 2007

Authors:

Emmerson M. Reis, Wander L. Vasconcelos, Herman S. Mansur, Marivalda Pereira

Keywords:

Bioactive Glass, Chitosan (CS), Hybrid, Scaffold, Tissue Engineering

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© 2008 Trans Tech Publications Ltd. All Rights Reserved

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