The Design and Simulation of HPLC’s Structure

Abstract:

As an important part of chromatography instruments, chromatographic column plays an important role in the progress of science and the development of production. In order to avoid the traditional process ,design - processing- test - Fixed design - re-processing and effectively shorting the design cycle save a lot of manpower, material and financial resources. This paper offers to watch the changes of flow profile within the column by the application of simulation software ANSYS CFX .Besides, according to the distribution of flow profile, the traditional column has been done a lot of dynamic simulation, especially the stigma part of the column. From a fluid Machinery perspective, we simulated and designed the structure, and then found out the best separation efficiency of the column structure.

• Periodical: Advanced Engineering Forum (Volumes 2-3)
• Pages: 984-987
• DOI: https://doi.org/10.4028/www.scientific.net/AEF.2-3.984
• Online since: December 2011
• Authors: Ze Ning Xu, Xiao Xia Wang, Liang Hou, Lei Gang Liu
• Keywords: ANSYS CFX Fluid Simulation, Chromatographic Column, Structure Optimization

References

[1] Ruonong Fu . Introduction to chromatographic analysis. Beijing: Chemical Industry Press, (2005).

[2] Fujun Wang. Computational Fluid Dynamics-CFD software principles and applications. Beijing: Qinghua University Press, (2004).

[3] Hong Xu, Hou Jian. The type of HPLC column and the selection method of mobile phase. Measurement and Testing Technology, (2010).

[4] Dong QiangLu. Shi QiangDai. Surface and inerfacial gravity waves due to a disturbance steadily moving in a two-layer inviscid fluid. ScienceDirect Journal of Hydrodynamics, 2010, 22(5): 40-44.

DOI: 10.1016/s1001-6058(09)60166-9

[5] Erik.H. & Edit.F. & K. Agnes, Effect of long-term storage and use on the properties ofreversed-phase liquid surfactant. Talanta, 2008(76)172-182.