This paper mainly investigate the accuracy of the computed drag on the DLR-F6 Wing-Body configuration, and analyze effect of grid and the turbulence models including the Spalart-Allmaras model, Wilcox’s k-ω model and Menter shear-stress transport model on aerodynamic forces for wing-body configuration. The computed results show that grid refinement has little effect on the pressure distributions, significant effect on drag. The turbulence models have certain effects on the pressure distributions, especially positions of the shock wave. They have obvious effects on drag, particularly friction drag. This study shows that performing the CFD calculation at the same angle-of-attack as experiment resulted in good comparisons with wing surface pressures.