To clean the spilled oil from wreck ships and protect the marine ecological balance and prevent the damage to marine environment, the simulation of oil spill in deep water with the wave motion, wind and current was built in FLUENT platform. The dispersion and diffusion of oil spill in deep water was simulated dynamically. Also the oil spilling trajectories under the conditions of different current velocities, wavelengths and wind velocities were compared and analyzed, respectively. The results showed that the current, wind and wave decided the location and areas of oil films on the sea surface. The water depth influenced by the wave which increased with the increasing wavelength. Meantime, the areas of oil films on sea surface increased with current velocity decreasing, while the distance between the oil film and the source of oil increased. With the wind velocity increasing, the extended length of oil dispersion underwater and the oil film area on surface increased.