A kind of drug release bionic scaffold with gradient structure was designed to release drugs. The scaffold mould had been designed with CAD software and fabricated with rapid prototype. The bionic beta-tricalcium phosphate (β-TCP) scaffold was fabricated with freeze drying. It was composed of two coaxial cylindrical porous scaffolds. The internal loose scaffold was embedded in the outer dense layer. The two different density layers of the scaffold could be used to adjust the drug releasing rate through regulating the slurry concentration. The scaffold was distributed with pores ranged from 30μm to 100μm. The research indicated that the scaffold with gradient structure could be loaded with two kinds of drugs which were released at different rate. The scaffolds were fit as the substitute materials for bone repairing.