For the design and development problems about intelligent Manufacturing Execution System of tungsten powder processing, the difficulty in the manufacturing execution management is pointed out combining Tungsten powder process flow. Goal of the system is analyzed and its main function is designed. Collaboration as the core, integrated system architecture is established from three aspects of system function, time and space. The physical data model is designed by using PowerDesigner, the manufacturing execution system is developed based on JSP. Through practical enterprise application, it is proved that the system immensely enhance the manufacturing execution management level for the Tungsten powder processing enterprise.