The majority of traffic accidents on the highway is rear-end collision. According to statistics about ninety percent rear-end collision can be avoided if there is 1 second pretreatment time for drivers. So it is necessary to develop automotive rear-end collision warning system to prevent the occurrence of accidents. The anti-rear-end collision warning system based on Zigbee technology is designded in this paper. Vehicle speed, acceleration and other traffic information among the nodes can be exchanged on real-time by using self-organizing wireless sensor networks consisted by Zigbee network nodes. A vehicle safe distance model is established after considered the effects of other traffic safety factors, and then, the actual distance measured by radar is compared with the safe distance so as to provide early warning, alarm and other driving information to drivers. The experiment results show that the system can effectively provide early warning, avoid rear-end collision, and improve active safety of vehicles.