Non-uniformity of the asphalt pavement is one of most important reason for early disease, control of non-uniformity in the production process of asphalt pavement is an important measure to ensure that quality and service life of pavement. Nuclear density gauge (PQI) can be non-destructive, rapid detection of asphalt pavement density. This paper give a research and application on the PQI calibration, testing frequency, the control parameters and evaluation index, and proposes a control method of non-uniformity in asphalt pavement construction with PQI. Asphalt pavement quality control in construction process can use this method. It is important to improve the stability of asphalt pavement quality and reduce the incidence of disease, and also has a certain reference value for establishing the quality control and quality assurance systems.