Influence of Impeller Design on Hemolysis of an Axial Blood Pump

Abstract:

Compared to centrifugal blood pumps, the high rotating speed of axial blood pumps lead to blood damage more easily. In order to improve blood compatibility of the axial blood pump developed by the authors, traditional method and three-dimensional streamlined method are used for axial impeller design, and rapid prototyping with ABS organic materials are adopted. Finally, hydraulic experiments and hemolysis tests have been conducted. The results reveal that the impeller design and the design parameters (diameter and length) affect the hydraulic performance and hemolysis of the axial pump obviously. The hemolysis index in axial flow impeller pump using traditional method is 0.12, while the minimum value of hemolysis index in the streamlined axial blood pump is 0.06, below the permitted hemolysis value of 0.1.

• Periodical: Applied Mechanics and Materials (Volume 140)
• Pages: 162-166
• DOI: https://doi.org/10.4028/www.scientific.net/AMM.140.162
• Online since: November 2011
• Authors: Lei Liu, Fang Qun Wang, Qin Lin Wu, Wen Jue Wu, Kun Xi Qian, Jing Hua Ji, Wen Xiang Zhao, Wei Xing He, Tian Bo Li
• Keywords: Axial Blood Pump, Hemolysis, Impeller Design

References

[1] American Heart Association, Dallas, TX, Heart Disease and Stroke Statistics—2003 Update, (2003)

[2] J. Litmathe, U. Boeken, P. Feindt, R. Marktanner and E. Gams. Mechanical Assist Devices as Bridging Systems to Transplantation: A Current Review, Possible Risks, and Perspectives. Proceedings, 36:3123–3128, 2004.

DOI: 10.1016/j.transproceed.2004.10.082

[3] F.Q. Wang, L. Li and Z.G. Feng, Prediction of Shear Stress-related Hemolysis in Centrifugal Blood Pumps by Computational Fluid Dynamics, Progress in Natural Science, vol. 15. no.10, pp.951-955, 2005.

DOI: 10.1080/10020070512331343160

[4] A. Garon, M.I. Farinas, Fast Three-dimensional Numerical Hemolysis Approximation, .Artificial Organs, 28(11), pp.1016-2004.

DOI: 10.1111/j.1525-1594.2004.00026.x

[5] B. Hentschel, I. Tedjo, M. Probst, M. Wolter, M. Behr, C. Bischof and T. Kuhlen, Interactive Blood Damage Analysis for Ventricular Assist Devices, IEEE Transactions on Visualization and Computer Graphics, vol.14, no.6, pp.1515-1522, November.-December. 2008.

DOI: 10.1109/tvcg.2008.142

[6] N.A. Greatrex, D.L. Timms,N. Kurita, E.W. Palmer and T. Masuzawa, Axial Magnetic Bearing Development for the BiVACOR Rotary BiVAD/TAH, IEEE Transactions on Biomedical Engineering, vol.57, no.3, pp.714-721, March 2010.

DOI: 10.1109/tbme.2009.2033389

[7] S.G. Chopski, W.B. Moskowitz and S.D. Gullquist, Numerical, Hydraulic and Hemolytic Evaluation of an ntravascular Axial Flow Blood Pump to Mechanically Support Fontan Patients, Annals of Biomedical Engineering, vol. 39, no. 1, pp.324-336, January. 2011.

DOI: 10.1007/s10439-010-0159-3

[8] G. Lei, Smith, A. William, Evaluation of computational models for hemolysis estimation, ASAIO Journal, vol. 51, no. 3, pp.202-207, May/June. 2005.

[9] R. Kosaka, T. Yamane, O. Maruyama, M. Nishida and T. Yada,Improvement of Hemolysis in a Centrifugal Blood Pump with Hydrodynamic Bearings and Semi-Open Impeller, Engineering in Medicine and Biology Society, 2007. EMBS 2007. 29th Annual International Conference of the IEEE, pp.3982-3985, 22-26 August. 2007.

DOI: 10.1109/iembs.2007.4353206