Extrusion force plays a significant role on sheet metal extrusion process. It is characterized by various process parameters including material properties, extrusion ratio, friction, tool shape etc. In this paper, a reasonable FEM model of sheet metal extrusion process was established and validated by comparing the results of simulation and experiment firstly. Based on the reliable model, the effect on extrusion force of various process parameters was investigated with orthogonal experimental design combined FEM simulation. The work presented in this paper has laid certain foundation for further work of modeling and optimizing extrusion force.