Continuous Preparation of Low-Molecular-Weight Chitosan by the Combination of Ozone Treatment and Membrane Separation

Abstract:

The continuous production of water-soluble low-molecular-weight chitosan (WSLMWC) was successfully achieved with an innovative continuous production system which consisted of ozone generating subsystem, degradation subsystem, and fractionation subsystem. The continuous production of the WSLMWC was performed through three uninterrupted steps: the first, the continuous preparation of the ozone from compressed oxygen, the second, the continuous degradation of chitosan by ozone treatment, and the last, the continuous fractionation of the WSLMWC from the degraded chitosan solution (DCS) by ultrafiltration (UF) membrane. The DCS as the most suitable feed supplied to UF membrane was ascertained. Three different WSLMWC products as useful materials in biomedicine and food were obtained, namely LMWC-3KDa, LMWC-5KDa, and LMWC-10KDa.

• Periodical: Applied Mechanics and Materials (Volume 189)
• Pages: 16-20
• DOI: https://doi.org/10.4028/www.scientific.net/AMM.189.16
• Online since: July 2012
• Authors: Chao Wei, Jin Tian Liang, Wu Yue, Ping Jia Yao
• Keywords: Degradation of Chitosan, Low-Molecular-Weight Chitosan (LMWC), Ozone, UF Membrane

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