Ferrocene-Based with Thiadiazole Antibacterial Agents: Synthesis, Characterization, and Biological Evaluation

Da Wei Yin; Xiao Ming Sun; Yu Ting Liu

doi:10.4028/www.scientific.net/AMM.189.181

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Ferrocene-Based with Thiadiazole Antibacterial Agents: Synthesis, Characterization, and Biological Evaluation
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HomeApplied Mechanics and MaterialsApplied Mechanics and Materials Vol. 189Ferrocene-Based with Thiadiazole Antibacterial...

Ferrocene-Based with Thiadiazole Antibacterial Agents: Synthesis, Characterization, and Biological Evaluation

Abstract:

A series of ferrocene schiff bases derived from Thiadiazole have been synthesized and characterized by IR, 1H NMR, and elemental analysis, the results conformed well with expected structures. The synthesized compounds were screened in vitro for their antibacterial activity against three Gram-negative (Escherichia coli, Pseudomonas aeruginosa, and Salmonella typhi) and two Gram-positive (Bacillus subtilis and Staphylococcus aureus) bacterial strains. The results showed that these compounds are a series potential new drugs in antibacterial activity against one or more species.

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Periodical:

Applied Mechanics and Materials (Volume 189)

Pages:

181-184

DOI:

https://doi.org/10.4028/www.scientific.net/AMM.189.181

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Online since:

July 2012

Authors:

Da Wei Yin, Xiao Ming Sun, Yu Ting Liu

Keywords:

Antibacterial Activity, Ferrocene, Gram-Negative, Gram-Positive, Schiff-Base, Thiadiazole

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