Wireless sensor networks are going to play a more and more important role in applications of next generation manufacturing systems. In this paper, we present a secure and intelligent wireless sensor network framework for manufacturing monitoring. We try to solve the problem of manufacturing monitoring from a new point of view. We introduce the layered architecture of the wireless sensor network framework in detail. Considering the vulnerable feature of Wireless sensor network, we also propose a secure mechanism based on the structure of wireless sensor network by using the anomaly detection technology. The major contribution of this paper is that we integrate wireless sensor network with secure and intelligent technologies to improve the overall performance of manufacturing monitoring.