Alginate-Based Multi-Membrane Hydrogel for Dual Drug Delivery System

Abstract:

Article Preview

Multi-membrane hydrogels are newly promising carriers in biomedical fields for their gentle gel condition and excellent biocompatibilities. In this study we focused on the dual control release property of alginate-based onion-like multi-membrane hydrogels hybrid with polylactic acid microspheres. The results indicated that the PLA microspheres evenly distributed in each of the hydrogel membranes. And the drug delivery in physiological saline is well controlled which can be promising in transport drugs, genes, protein, etc.

Info:

Periodical:

Edited by:

Guangfan Li and Chaohe Chen

Pages:

1632-1635

DOI:

10.4028/www.scientific.net/AMM.275-277.1632

Citation:

S. J. Wei et al., "Alginate-Based Multi-Membrane Hydrogel for Dual Drug Delivery System", Applied Mechanics and Materials, Vols. 275-277, pp. 1632-1635, 2013

Online since:

January 2013

Export:

Price:

$35.00

[1] Van Vlierberghe, S., P. Dubruel, and E. Schacht, Biomacromolecules, 1387-408, (2011), p.12.

[2] N.A. Peppasa, P.B., W. Leobandunga, H. Ichikawab, European Journal of Pharmaceutics and Biopharmaceutics, 20, (2000), p.27.

[3] Guo J in tang, L. i.X., L iL ing, Chemistry Bulletboard, (2004), p.198.

[4] Despang, F., et al., Materialwissenschaft und Werkstofftechnik, 761-767, (2005), p.36.

[5] Lin, H.R. and Y.J. Yeh, J Biomed Mater Res B Appl Biomater, 52-65, (2004), p.71.

[6] Balakrishnan, B. and R. Banerjee, Chemistry Review,4453-74, (2011), p.111.

[7] Bae, S.E., et al., J Control Release, 37-43, (2009), p.113.

[8] Simó, C., A. Cifuentes, and A. Gallardo, Journal of Chromatography B, 37-49, (2003), p.797.

[9] Langer, R. and J.P. Vacanti, Science (New York, N.Y. ), 920-6, (1993),p.260.

[10] Peppas, N.A., et al., European Journal of Pharmaceutics and Biopharmaceutics, 27-46, (2000),p.50.

[11] Wei, L., et al., Biomaterials,2606-13, (2009), p.30.

[12] Xia, W., et al., Eur J Pharm Biopharm, 546-52, (2008), p.69.

[13] Choi, D.H., et al., J Control Release, 193-201, (2010), p.147.

[14] Guo J in tang, L. i.X., L iL ing, China Academic Journal 3, (2004).

[15] Bodmeier, R. and J.W. McGinity, Journal of microencapsulation, 279-88, (1987), p.4.

[16] Dai, H., et al., Soft Matter, 1987, (2009), p.5.

[17] Li Lei, L.L., Zhou. CR., Xu. ZC., Applied Mechanics and Materials, 5, (2012), p.58.

In order to see related information, you need to Login.