Studying on the Polymorphs and the Melting Point of HMP

Hui Wu Li; Zuo Liang Sha

doi:10.4028/www.scientific.net/AMM.291-294.1661

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HomeApplied Mechanics and MaterialsApplied Mechanics and Materials Vols. 291-294Studying on the Polymorphs and the Melting Point...

Studying on the Polymorphs and the Melting Point of HMP

Abstract:

Polymorphs is present in many crystalline drug, different crystal type tend to produce different effects. Drug quality and curative effect of the important quality index is drug heteromorphic stability .The change of drug heteromorphic will change the nature, quality, efficacy of the drug. Generally speaking, the greater the crystal particle size, heating melting needs more energy, the more stable. The crystal type which has high melting point, the chemistry stability is good, but the solubility and digestion rate is low. HMP has different polycrystalline forms, at present reports in the literature there are two kinds of crystal type, form Ⅰ and form Ⅱ. The form Ⅰ is more stable than form Ⅱ, and has higher melting point. This article research the relationship between HMP polymorphism and melting point based with the drug melting point meter and DSC.

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Periodical:

Applied Mechanics and Materials (Volumes 291-294)

Pages:

1661-1665

DOI:

https://doi.org/10.4028/www.scientific.net/AMM.291-294.1661

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Online since:

February 2013

Authors:

Hui Wu Li, Zuo Liang Sha

Keywords:

Differential Scanning Calorimetry (DSC), Melting Point, Polymorphs

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