Physicochemical Characterization of the Inclusion Complex of Diosmetin with Hydroxypropyl-β-Cyclodextrin

Yan Zhang; Korbanjhon Brad

doi:10.4028/www.scientific.net/AMM.295-298.298

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HomeApplied Mechanics and MaterialsApplied Mechanics and Materials Vols. 295-298Physicochemical Characterization of the Inclusion...

Physicochemical Characterization of the Inclusion Complex of Diosmetin with Hydroxypropyl-β-Cyclodextrin

Abstract:

In this study, the inclusion complex of diosmetin with hydroxypropyl-β- -cyclodextrin (HP-β-CD) was prepared to improve the water solubility of diosmetin by the solvent method. The content of diosmetin in the complex was determined by UV. And the physicochemical properties of the complex were analyzed by ultraviolet-visible spectrometry (UV), infrared spectrometry (IR), X-ray diffractometry (XRD), differential scanning calorimetry (DSC). The results showed that the physical phase of diosmetin had been changed. It was completely dispersed in HP-β-CD. HP-β-CD and diosmetin were combined by non-covalent bonds.