Tribological Analysis and Optimization of Polymer Prosthetic Components as Drug Delivery Systems

Monica Cretan  Stamate; Ciprian Stamate

doi:10.4028/www.scientific.net/AMM.332.521

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HomeApplied Mechanics and MaterialsApplied Mechanics and Materials Vol. 332Tribological Analysis and Optimization of Polymer...

Tribological Analysis and Optimization of Polymer Prosthetic Components as Drug Delivery Systems

Abstract:

This paper analyzes the tribological properties of a polymer prosthetic component, which was optimized by coating polymer layers containing medicinal substances. Polymer component is made of ultra high molecular weight polyethylene (uhmwpe) and is used in prosthetic hip replacement for acetabular cup with a metal component of cobalt-chromium alloy molybdenum. Polymer surface was covered with a layer of polyvinyl alcohol hydrogel superporos containing the drug substance ketoprofen-cyclodextrin complex. Studies consisted in evaluating drug substance release during 12 hours and tribological evaluation of polymer surface in simulated physiological conditions using cetr-umt-2 device.

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Periodical:

Applied Mechanics and Materials (Volume 332)

Pages:

521-526

DOI:

https://doi.org/10.4028/www.scientific.net/AMM.332.521

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Online since:

July 2013

Authors:

Monica Cretan Stamate, Ciprian Stamate

Keywords:

Component, Drug Delivery System, Polymer, Prosthesis, Wear

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References

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