Modeling, design and fabrication of tissue scaffolds with intricate architecture, porosity and pore size for desired tissue properties presents a challenge in tissue engineering. Based on comparison and analysis of the two kinds of existing unit cells, the new micropore unit cell with a sphere hole in the middle and three cylindrical holes in the edge was gained. The negative model of bearing human bone was designed according to the new unit cell. Boolean Operation to the negative mode and entity contour profile, then the interconnected scaffold of artificial bone with certain porosity and gradient micropore was obtained. The results of simulation show that the average modulus of the model is 8.5Gpa, and the porosity is from 25.8% to 42.7%. It can meet the mechanical and biomimetic requests of bearing human artificial bone.