Monitoring the Coating Thickness of Pharmaceutical Tablets with MaxGWMA Control Chart

Abstract:

So as to monitor and detect small shifts in the mean and variability of a manufacturing process, exponentially weighted moving average (EWMA) control charts are widely employed. Some of its extensions have been proposed to improve its performance. Among them, the Maximum generally weighted moving average (MaxGWMA) control chart is found as the superior. In the industry of coating pharmaceutical tablets, controlling the thickness of the coating layer containing active pharmaceutical ingredients is of great importance and in order to keep track on the coating quality, various methods using modern technologies have been proposed. However, decision support systems on the status of the coating process are not fully developed. Hence, in this study, MaxGWMA control chart was proposed to monitor the coating thickness of the tablets so that any small shift in the coating process can be quickly detected and further corrective actions can be implemented to make the process in control.

• Periodical: Applied Mechanics and Materials (Volume 372)
• Pages: 325-330
• DOI: https://doi.org/10.4028/www.scientific.net/AMM.372.325
• Online since: August 2013
• Authors: Thanh Lam Nguyen, Ming Hung Shu, Bi Min Hsu
• Keywords: Coating Thickness, Control Chart, MaxGWMA, Pharmaceutical Coating

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