Compatibility between Paclitaxel and Polymer Carrier

Wen Zhao; Wen Long Liu; Jie Liang Wang

doi:10.4028/www.scientific.net/AMM.420.263

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HomeApplied Mechanics and MaterialsApplied Mechanics and Materials Vol. 420Compatibility between Paclitaxel and Polymer...

Compatibility between Paclitaxel and Polymer Carrier

Abstract:

Several polymer-based drug delivery systems are being developed to enhance the extremely low water-solubility of paclitaxel (PTX). It is believed that there is a positive correlation between the compatibility of polymer-drug and the solubilization. In recent years, solubility parameters for polymer and drug were used to evaluate degree of compatibility between a drug and a polymer, which were measured using various experimental methods or estimated using the group contribution menthod (GCM). In this study, degree of compatibility between PTX and polymers were estimated by molar free energy of mixing (Δ̗_mix) that was calculated through computer simulation. It is found that the degree of compatibility is: PTX-PTRP > PTX-PLBG > PTX-PLGA > PTX-PCL > PTX-PLA. It has been demonstrated that the result of this study is in accord with the Similar Dissolve Mutually Theory.

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Periodical:

Applied Mechanics and Materials (Volume 420)

Pages:

263-268

DOI:

https://doi.org/10.4028/www.scientific.net/AMM.420.263

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Online since:

September 2013

Authors:

Wen Zhao, Wen Long Liu, Jie Liang Wang

Keywords:

Compatibility, Paclitaxel, Polymer, Simulation

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