Study on Mechanical Properties for Modeling and Simulation of Microneedles for Medical Applications

Yan Li; Pei Yu Zhang

doi:10.4028/www.scientific.net/AMM.454.86

Paper Titles

Study on Mechanical Engineering for Flight with Flight Safety Evaluation Method on Relevance Vector Machine
p.70

Study Based on Hybrid Bounding Volume Hierarchy for Collision Detection in the Virtual Manipulator
p.74

Fault Analysis and Treatment of CNC Machine Tool Servo System
p.78

Research and Design of Walking Mechanism of Robot and the Parameterization Modeling Based on the UG
p.82

Study on Mechanical Properties for Modeling and Simulation of Microneedles for Medical Applications
p.86

Extended NGM (1,1,K) Model and its Application to Spectral Prediction of Military Launch Vehicle Hydraulic System
p.90

Study on Mechanical Wear State in Military Launch Vehicle Hydraulic System with Knowledge Discovery from Analytical Ferrography
p.94

The Study of the Parameterization of the Drum Brake Design Based on UG
p.98

Study on Error Analysis of On-Line Measurement System Based Numerical Control Process
p.102

HomeApplied Mechanics and MaterialsApplied Mechanics and Materials Vol. 454Study on Mechanical Properties for Modeling and...

Study on Mechanical Properties for Modeling and Simulation of Microneedles for Medical Applications

Abstract:

A MEMS Microneedle Array was modeled, designed and simulated. The mechanical properties of the microneedle structure were theoretically analyzed including analysis of fracture strength and distribution of von mises stress. The conditions of initial insertion and after initial insertion were considered. The detail linear and nonlinear buckling analyses on needle structure were also presented. Two modes of buckling were come to and discussed. The fabrication of microneedle array was simulated by employing Intellisuate and bi-mask technique. The microneedle array can be used in microsystem for in-vivo fluid sampling and drug delivery.

You might also be interested in these eBooks

Research on Mechanical Engineering, Civil Engineering and Material Engineering

View Preview

Info:

Periodical:

Applied Mechanics and Materials (Volume 454)

Pages:

86-89

DOI:

https://doi.org/10.4028/www.scientific.net/AMM.454.86

Citation:

Cite this paper

Online since:

October 2013

Authors:

Yan Li, Pei Yu Zhang*

Keywords:

Buckling Analysis, MEMS, Microneedle Array, Simulation

Export:

RIS, BibTeX

Price:

Permissions CCC:

Request Permissions

Permissions PLS:

Request Permissions

Сopyright:

Citation:

* - Corresponding Author

References

[1] S. P. Davis, B. J. Landis, and etc., Insertion of microneedles into skin: measurement and prediction of insertion force and needle fracture force, J. Biomech., 37(8), 1155-63, (2004).

DOI: 10.1016/j.jbiomech.2003.12.010

Google Scholar

[2] M. R. Prausnitz, Microneedles for transdermal drug delivery, Adv. Drug Deliv. Rev. 56, 581-587, (2004).

DOI: 10.1016/j.addr.2003.10.023

Google Scholar

[3] P. Zhang, G. Wu et al. Bulk Silicon Holding Structures of Fibers for the Micromachined Optical Devices, Inter. Symp. Smart Structures and Microsystems 2000, Hong Kong.

Google Scholar

[4] F. Ericson and J. Schweitz, Micromechanical fracture strength of silicon. J. Appl. Phys. 68, 5840, (1990).

Google Scholar

[5] K. E. Petersen, Silicon as a mechanical material, Proc. The IEEE, 70, 5, 420-456, (1982).

Google Scholar